Protect your home from spiders and other unwelcome invaders with effective outdoor and indoor sprays. This guide highlights select proven products that address common spider problems—on porches, foundations, and interior entryways—while offering options for fast knockdown, long-lasting barriers, and pet-friendly formulations. Read on to compare features, usage, and coverage to choose the right solution for your space.
| Product | Brand | Primary Use | Notes |
|---|---|---|---|
| Ortho Home Defense Insect Killer for Indoor and Perimeter2 with Comfort Wand | Ortho | Ants, Roaches, Spiders, and more | Long-lasting barrier up to 12 months on non-porous surfaces |
| TERRO T2302 Spider, Ant, Roach, and Other Insects Killer Aerosol | Terro | Spiders, ants, cockroaches, crickets | Two spray bottles; kills on contact |
| Wet & Forget Miss Muffet’s Revenge Indoor/Outdoor Spider Killer | Wet & Forget | Spiders; indoor and outdoor barrier | Attached sprayer; up to 12 months protection |
| Mighty Mint Peppermint Oil Insect Repellent Spray | Mighty Mint | Spiders, ants, roaches | Plant-based; pet-friendly and family-safe |
| HOT SHOT Spider & Scorpion Killer Aerosol | HOT SHOT | Spiders and scorpions, including Black Widow | Fast-acting; up to 4 months residual |
Ortho Home Defense Insect Killer For Indoor And Perimeter2

Ortho’s Home Defense offers a comprehensive indoor and perimeter treatment that tackles a broad range of pests, including spiders. The Comfort Wand provides precise, targeted application, simplifying coverage around doors, windows, and entry points. A key feature is a long-lasting barrier designed to protect non-porous surfaces for up to 12 months, reducing recurring spider activity indoors and around the home’s exterior. The formula is suitable for kitchens and bathrooms as well as outdoor foundations, patios, and garages, making it a versatile option for integrated pest management.
TERRO Spider, Ant, Roach, and Other Insects Killer Aerosol Spray

Terro’s two-pack aerosol targets a broad spectrum of pests, including spiders, ants, cockroaches, and crickets. The spray delivers on-contact knockdown, making it suitable for rapid relief in high-traffic areas such as entryways and kitchens. Its dual-pack design offers extended use and flexibility for larger homes or multiple spray points. The formulation emphasizes immediate action to deter reinfestation and is best used as part of an ongoing pest control plan.
Wet & Forget Miss Muffet’s Revenge Spider Killer

Miss Muffet’s Revenge combines indoor and outdoor capability with a ready-to-use formula designed to kill spiders and create a barrier that lasts up to a year with a single application. It includes an attached sprayer for easy reach to corners and entry points, extending protection to hard-to-reach areas. The spray range reaches up to 10 feet, enabling efficient coverage along baseboards, ceilings, and outdoor eaves. For best results, apply to areas where spiders are found and avoid oversaturation.
Mighty Mint Peppermint Oil Insect Repellent Spray

This plant-based formula uses extra-concentrated peppermint oil to repel spiders, ants, and roaches. It is marketed as pet-friendly and family-safe when used as directed, making it suitable for homes with children and pets. The product is designed for versatile indoor and outdoor use, including baseboards, entryways, patios, and living spaces. While effective for deterrence, reapplication may be necessary in high-traffic zones or after rain exposure, and it should be applied to surfaces that can tolerate essential oils.
HOT SHOT Spider & Scorpion Killer Aerosol

Hot Shot Spider & Scorpion Killer combines rapid action with a residual effect intended to guard against spiders and scorpions for up to several months. The aerosol format allows for quick treatment of hiding spots, baseboards, and cracks where spiders may retreat. It specifically notes effectiveness against larger species and black widow hatchlings. Use in well-ventilated areas and avoid applying to surfaces that could be damaged by solvents. Suitable for exterior and interior use as part of a broader spider-management strategy.
Buying Guide: Key Purchase Considerations
- Scope of containment: Decide between indoor-targeted sprays, outdoor perimeter treatments, or a combination to cover entry points, foundations, and patios.
- Active ingredients and safety: Review plant-based and pet-safe options if you have children or pets, and consider quick-kill versus long-lasting barrier formulations.
- Application method: Wand applicators and attached sprayers offer precision for corners and baseboards, while aerosols provide rapid coverage for hard-to-reach spaces.
- Residual protection: Products advertising months of protection may reduce the frequency of reapplication, but weather and exposure can affect longevity.
- Target species: Some sprays are broad-spectrum; others focus on spiders or specific pests like black widows. Choose based on the most common invaders in your area.
- Coverage area: Check bottle or canister coverage to ensure the product meets the square footage of your home’s exterior and interior spaces.
- Reapplication guidance: Follow manufacturer directions regarding surface compatibility, proximity to food prep areas, and indoor-outdoor transition zones.
- Integrated pest approach: Consider combining a perimeter barrier with routine home-cleaning practices and sealant fixes to reduce spider harborage.